Acute knee pain

What If Your Knee Could Heal Itself?

December 08, 20253 min read

The Science Behind A Hopeful New Therapy

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New Treatment Hope for Knee Pain: What We Know About Wharton’s Jelly Stem Cells

If you have knee pain from arthritis, you know how hard it can make your life. Walking hurts, stairs are tough, and sometimes even getting out of a chair feels like a struggle. Many people try pills, shots, or physical therapy, but these don’t always stop the problem from getting worse.

Doctors are now studying a new treatment called Wharton’s Jelly stem cells, and early results are promising. Here’s what you need to know, explained in simple terms.

What Are Wharton’s Jelly Stem Cells?

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Wharton’s Jelly is a soft tissue found inside the umbilical cord after a baby is born. It is not harmful to the baby or the mother, and nothing painful is done to get it.

Stem cells from this tissue:

  • Can help calm inflammation

  • Can help the body heal better

  • Do not cause tumors

  • Are very young and healthy cells

These stem cells are injected into the knee to help reduce pain and improve movement.


What Did the Studies Look At?

Scientists reviewed six studies with 97 people who had knee arthritis or cartilage problems. The people were followed for 3 months to 4 years after treatment.

They received injections of Wharton’s Jelly stem cells directly into the knee.


What Did the Studies Find?

1. The treatment appears safe

Across all the studies:

  • No serious problems happened

  • No infections

  • No tumors

  • No joint damage

The most common issue was some swelling in the knee for a short time. It usually went away on its own.


2. Most people felt less pain

People said their knees hurt less after getting the stem cell injections. Many also said they could:

  • Walk better

  • Move more easily

  • Do daily activities with less discomfort

Several tests showed improvements, including pain scores and quality-of-life scores.


3. More than one injection may work better

Some studies found that people who got more than one injection had better results than those who got only one. This may be because stem cells work by calming inflammation over time.


4. MRI scans did not always show big changes

Even though many people felt better, MRI pictures of the knee didn’t always show major healing or new cartilage growth. This is normal because these stem cells may help the knee work better without showing large changes on an MRI.


Why These Stem Cells Stand Out

Wharton’s Jelly stem cells seem to work better than stem cells taken from an adult’s fat or bone marrow because they:

  • Are younger and more active

  • Can help reduce inflammation more strongly

  • Can grow and multiply faster

They also avoid the need for a painful procedure to take cells from your own body.


What We Still Need to Learn

Scientists still need bigger studies to learn:

  • The best dose

  • How many injections are needed

  • Who benefits the most

  • How long the results last

But so far, the research looks promising and hopeful.


Bottom Line

Wharton’s Jelly stem cell injections appear to be a safe and helpful new option for people with knee arthritis. They may reduce pain, improve movement, and help people avoid or delay surgery. While they are not a cure and do not always rebuild cartilage, they offer a promising new way to help people with chronic knee pain get their life back.

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Treatment of Knee Osteoarthritis and Chondral Injury with Umbilical Cord/Wharton’s Jelly-Derived Mesenchymal Stem Cells: A Systematic Review of Safety and Efficacy

Dr. Brian Petrie is a leading expert in functional medicine and chronic pain management, with over 30 years of dedicated experience. Renowned for his expertise and compassionate approach, Dr. Petrie is committed to enhancing the health and well-being of his patients.

Dr. Brian Petrie, DC, AFMC

Dr. Brian Petrie is a leading expert in functional medicine and chronic pain management, with over 30 years of dedicated experience. Renowned for his expertise and compassionate approach, Dr. Petrie is committed to enhancing the health and well-being of his patients.

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